Performance stayed in control
Levey–Jennings QC trending across the transition shows no shift, no trend, and no increase in outliers — every measured point remained within ±2 SD of the established mean.
Key findings
Outcomes for lab decision-makersSignal integrity preserved
Stable baseline performance and preserved signal integrity across all analytes following solvent transition.
~4× cost reduction
Approximately a four-fold cost reduction versus the incumbent supplier with no sacrifice in quality.
CAP proficiency maintained
All CAP proficiency testing events passed before and after implementation, with no corrective actions required.
Purpose of the evaluation
This evaluation examined the impact of transitioning the methanol, water, and isopropanol used in a laboratory-developed LC–MS/MS urine toxicology method to Birch Biotech solvents.
Analytical performance was assessed before and after implementation using multiple quality-control metrics and statistical approaches.
Executive summary
Across all analytes and QC levels, analytical accuracy and precision remained within predefined acceptance criteria following solvent transition.
Levey–Jennings and histogram analyses demonstrated stable QC performance with no solvent-related trends, shifts, or increases in outlier behavior.
System suitability monitoring confirmed preserved analytical sensitivity, with signal responses remaining well above limits of detection and quantitation.
Read the full evaluation
The complete LC–MS solvent transition analysis — including statistical evaluation, QC data, and system suitability results.