Independent Validation
Confident Solvent Switching
Low Risk. High Reward.
Switching LC–MS Solvents Without Jeopardizing Results
A third-party evaluation of Birch Biotech solvents in a 71-analyte LC–MS/MS urine toxicology method demonstrates stable performance, preserved sensitivity, and significant cost savings.
Key Findings
Three outcomes that matter most for laboratory decision-makers
Signal Integrity Preserved
Stable baseline performance and preserved signal integrity were observed across all analytes following solvent transition.
~4× Cost Reduction
Birch Biotech solvents provided approximately a four-fold cost reduction versus the incumbent supplier with no sacrifice in quality.
CAP Proficiency Maintained
All CAP proficiency testing events passed before and after implementation with no corrective actions required.
Purpose of the Evaluation
This evaluation examined the impact of transitioning methanol, water, and isopropanol used in a laboratory-developed LC–MS/MS urine toxicology method to Birch Biotech solvents.
The study assessed analytical performance before and after implementation using multiple quality control metrics and statistical approaches.
Methods & Metrics
- → Accuracy and precision metrics
- → Levey–Jennings QC trending
- → Westgard rule evaluation
- → Histogram distribution analysis
- → System suitability monitoring
Executive Summary
Across all analytes and QC levels, analytical accuracy and precision remained within predefined acceptance criteria following solvent transition.
Levey–Jennings and histogram analyses demonstrated stable QC performance with no solvent-related trends, shifts, or increases in outlier behavior.
System suitability monitoring confirmed preserved analytical sensitivity with signal responses remaining well above limits of detection and quantitation.
Read the Full Evaluation
Download the complete LC–MS solvent transition analysis including statistical evaluation, QC data, and system suitability results.
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